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To test for a time-dependent modulation of spectral power, specifically a decrease of beta power around the onset of a motor response, we compared epoched data to time-averaged power computed for each trial, channel, and frequency bin separately. For the serial reaction time task, this baseline was computed by taking the mean power across all time bins from the onset of a cue on the screen to the presentation of the next cue, i.e., the start of the following trial (Fig. 2A). For the economic decision making task the baseline was computed from 1 s before the onset of the options on the screen to 1 s after the offset of the outcome (Fig. 3A). To exclude the possibility that perimovement power deviations from baseline in the decision making task were due to outcome-induced power changes that entered the computation of baseline power, a control baseline period from 1 s before the onsets of options to the onset of the outcome was used (Fig. 3A).
While the frequency range of the observed perimovement power changes, as well as their direction and their close temporal association with movements, were similar, we found differences in their amplitude and duration between the two tasks. Specifically, peak t-values for the perimovement alpha/beta modulation were larger for the value-based decision making task compared with the serial reaction time task (see color scaling in Fig. 2B vs. Fig. 3B). In principle, this could reflect differences in the time intervals used to compute baseline power in the two tasks. In the serial reaction time task, patients prepared and executed a motor response during most of the time over which baseline power was computed. Perimovement deviations from this baseline are therefore expected to be relatively small compared with the value-based decision making task, where baseline periods included parts of the intertrial interval as well as longer pre- and postmovement periods.
Second, given the short reaction times and intertrial intervals in the serial reaction time task, we cannot exclude the possibility of a temporal overlap of signals from consecutive trials in that task. For example, it is possible that a postmovement increase in the power of alpha/beta oscillations, as observed in patients P1, P2, P3 and P5, might overlap with the premovement alpha/beta decrease during preparation of the subsequent response in these patients. In this case, the former would be expected to partially mask the latter. Because of its long, variable intertrial interval and long response times, there is no such overlap between signals from consecutive trials in the decision making task, where we observe a pattern of perimovement alpha/beta modulation similar to that in the serial reaction time task. 1e1e36bf2d